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KMID : 0191120210360430306
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Journal of Korean Medical Science
2021 Volume.36 No. 43 p.306 ~ p.306
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A Case Report of Immune Thrombocytopenia after ChAdOx1 nCoV-19 Vaccination
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Kim Gyung-Ah
Choi Eun-Ji
Park Han-Seung
Lee Jung-Hee
Lee Je-Hwan
Lee Kyoo-Hyung
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Abstract
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Immune thrombocytopenia (ITP) is an autoimmune condition characterized by platelet destruction through antibody-mediated mechanism. ITP is one of the manifestations of a coronavirus disease, as well as an adverse event occurring after vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Several cases of ITP have been described after vaccination with two mRNA-based vaccines?BTN162b2 (Pfizer-BioNTech) and mRNA-1273 (Moderna)?against SARS-CoV-2. Herein, we report a case of ITP occurring after vaccination with ChAdOx1 adenovirus vector nCoV-19 (AstraZeneca) vaccine in Korea. A 66-year-old woman presented with multiple ecchymoses on both upper and lower extremities and gingival bleeding, appearing 3 days after receiving the first dose of ChAdOx1 nCoV-19. Her laboratory results showed isolated severe thrombocytopenia without evidence of combined coagulopathy. She was diagnosed with ITP and successfully treated with high-dose dexamethasone and intravenous immunoglobulin. Clinical suspicion to identify vaccine-related ITP is important to promptly initiate appropriate treatment.
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KEYWORD
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COVID-19, SARS-CoV-2, ChAdOx1 nCoV-19, Immune Thrombocytopenia
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